Webactivities has rendered these alkaloids popular targets in total synthesis.5–8 Specifically, the biosynthetic interrelationship of these compounds has inspired several unified synthetic strategies towards their synthesis.6j,7f,8 Nevertheless, only a handful of enantioselective total syntheses have been reported.7,8 WebNatural products : The total syntheses of asperchalasines A–E, a collection of unprecedented cytochalasan‐epicoccine heterotrimer and ‐dimers, have been completed. The key elements of the syntheses include a series of bio‐inspired Diels–Alder reactions to forge the hetero‐dimers and a biomimetic oxidative [5+2]‐cycloaddition to assemble the …

Collective total syntheses of cytochalasans and merocytochalasans

WebApr 9, 2024 · The asymmetric total syntheses of (+)-vulgarisins A-E, which share a rare … WebThe first total syntheses of asperchalasines A‐E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through a unified approach that hinges on a Diels‐Alder reaction and an RCM reaction. The bioinspired Diels‐Alder reactions of aspochalasin B with different … rock fish fabric

Yefeng TANG and Gang LIU publish "Total Syntheses of …

http://capricorn.bc.edu/lsy/public_html/files/total-synthesis/2024-12-18_Xinyu-Yang_AsperchalasinesA-E.pdf Web4. Single-step enantioselective synthesis of mechanically planar chiral [2]rotaxanes using a chiral leaving group strategy C. Tian†; S. D. P. Fielden†; B. Pérez ... WebJun 6, 2016 · The first and collective total syntheses of periconiasins A-E, a group of naturally occurring cytochalasans, were achieved by a series of rationally designed or bioinspired transformations. Salient features of the syntheses include a tandem aldol condensation/Grob fragmentation to assemble the linea … other corona virus